Aflibercept (Into the eye)


Aflibercept (a-FLIB-er-sept)

Treats neovascular (wet) age-related macular degeneration (AMD) and macular edema after retinal vein occlusion.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine


  • A nurse or other health provider will give you this medicine.
  • Depending on your condition, this medicine is given as a single shot into the eye once every 4 weeks, or once every 4 weeks for the first 3 months and then once every 8 weeks.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have glaucoma or other eye problems.
  • This medicine may increase your risk of blood clots. Check with your doctor right away if you have chest pain, sudden headache or weakness, or trouble breathing, walking, or talking. Make sure your doctor knows if you have a history of blood clot problems, heart attack, or stroke.
  • The pressure inside your eye could get too high after you are given this medicine. Your doctor may need to monitor your eye, especially during the first hour after the injection. Tell your doctor right away if you feel sudden or severe eye pain or a headache, have blurry vision, or see halos around lights.
  • Tell your doctor right away if your eye becomes red, painful, or sensitive to light. Also tell him if you see flashes or sparks of light, or have a change in vision.
  • This medicine may cause temporary blurred vision. Avoid driving, using machines, or doing anything else that could be dangerous if you are not able to see well.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bleeding in your eye
  • Blurred vision, seeing floating spots
  • Chest pain, trouble breathing, coughing up blood
  • Eye pain, swelling or redness of your eyes or eyelids
  • Eye redness, sensitivity to light, vision change
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Pain in your lower leg (calf), trouble walking or talking
  • Sudden or severe headache

If you notice these less serious side effects, talk with your doctor:

  • Watery eyes, feeling that something is in your eye

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 4/4/2014

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.