Apixaban (By mouth)
Prevents stroke and blood clots. This medicine is an anticoagulant (blood thinner).
When This Medicine Should Not Be Used
How to Use This Medicine
- Take your medicine as directed.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can affect how apixaban works. Tell your doctor if you are taking any of the following:
- Another blood thinner, such as clopidogrel, heparin, prasugrel, warfarin
- An NSAID pain or arthritis medicine, such as aspirin, diclofenac, ibuprofen, naproxen
- Depression medicine, such as citalopram, fluoxetine, sertraline
- Infection medicine, such as clarithromycin, itraconazole, ketoconazole, rifampin, ritonavir
- Seizure medicine, such as carbamazepine or phenytoin
- St John's wort
Warnings While Using This Medicine
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, an artificial heart valve, or a history of bleeding problems.
- Do not suddenly stop taking this medicine without asking your doctor. You have a higher risk of stroke for a short time after you stop using this medicine.
- This medicine increases your risk for bleeding that can become serious if not controlled. It may take longer than usual for bleeding to stop.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bleeding that will not stop, unusually heavy vaginal bleeding, or frequent nosebleeds
- Chest pain, trouble breathing
- Coughing up or vomiting blood or material that looks like coffee grounds
- Feeling dizzy or faint
- Joint pain or swelling
- Red or black, tarry stools
- Red or pink urine
- Unusual bleeding, bruising, or weakness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last reviewed on 4/4/2014
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