Treatment is aimed at reducing sebum production, helping the skin shed dead cells so they do not build up, and preventing bacteria from accumulating. Early treatment is essential to prevent scarring. You can help by doing the following:
- Wash skin once or twice a day with a mild cleanser. Washing more often, scrubbing skin, or using facial masks can make acne worse.
- Use oil-free skin care products and cosmetics. Look for products that say "water based" or "non comedogenic."
- Try over-the-counter lotions containing benzoyl peroxide or salicylic acid.
- People with mild cases of acne may reduce symptoms with herbs, Ayurveda, or homeopathy. You may have to use medicines or complementary and alternative remedies for at least 6 to 8 weeks before seeing a noticeable improvement in symptoms.
Topical formulations are usually the first line therapy for acne. They are used to prevent and treat acne. Your doctor may also prescribe topical medicines to treat acne. The most commonly used include:
- Retinoids (tretinoin or Retin-A, adapalene or Differin, and tazarotene or Tazorac). These are medicines derived from vitamin A that work by unclogging pores and reducing inflammation. Side effects may include redness, peeling, and photosensitivity (high risk of sunburn). Most retinoids are applied at night. Pregnant women should not use topical retinoids during pregnancy. Acne may worsen during the first 3 to 4 weeks of retinoid therapy before improving.
- Antibiotics. Antibiotics work by killing bacteria and reducing inflammation. Topical antibiotics, such as clindamycin or erythromycin, are available in prescription form. They may be used to treat mild-to-moderate acne.
- Benzoyl peroxide. Benzoyl peroxide is also available in prescription form. Benzoyl peroxide may irritate the skin and cause peeling. Water-based formulations of the lowest strength are least irritating.
Your doctor may recommend a combination of topical medicines, such as benzoyl peroxide and clindamycin, or tretinoin (a retinoid) and clindamycin. Older topical preparations, such as sulfur, resorcin, and salicylic acid are still useful, particularly when newer medicines are not well tolerated.
Your doctor may prescribe oral (taken by mouth) antibiotics either alone or in addition to topical medications for moderate-to-severe acne. For those with severe, inflammatory acne that does not improve with other medications, an oral retinoid called isotretinoin (Accutane) may be prescribed.
- Antibiotics. Antibiotics work by killing bacteria and reducing inflammation. Commonly prescribed oral antibiotics include doxycycline, minocycline, and tetracycline. Pregnant women and children younger than 9 should not take these antibiotics. Side effects may include gastrointestinal upset and vaginal itching.
- Isotretinoin (Accutane). Doctors are not sure exactly how isotretinoin works, although it may reduce the production of sebum. It is usually prescribed for people with severe, inflammatory acne that does not get better with other medicines. Isotretinoin is taken twice a day for 20 weeks. It causes severe birth defects and must not be used by pregnant women, or those who may become pregnant. In fact, in the U.S. women who take isotretinoin are required to undergo regular pregnancy tests and take some form of prescription birth control. Isotretinoin also has many side effects, some potentially serious, that warrant limiting its use to serious cases of acne.
Some women may be prescribed birth control pills that seem to reduce acne.
Surgery and Other Procedures
Surgery or other procedures may help improve the appearance of skin scarred by acne. Chemical peeling (where a chemical solution is applied to the skin that causes it to blister and eventually peel off) can reduce minor scars. Dermabrasion (a procedure that uses a rapidly rotating brush to remove the top layers of skin) can help more severe scarring. Laser resurfacing uses pulses of light to remove the top layer of skin and reduce scarring. However, few studies have compared light and laser therapy with conventional acne treatments.
Complementary and Alternative Therapies
Complementary and alternative therapies (CAM) may play a role in the treatment of acne. You should work with a knowledgeable provider and inform all of your physicians about any CAM therapies you are planning on using. Some CAM therapies may interfere with conventional treatments and may not be right for every person.
Some studies suggest that foods with a high gycemic load, such as processed snacks, refined sugar, and baked goods, may exacerbate acne. Dairy intake also appears to be weakly associated with acne. A low glycemic diet helps keep blood sugar stable and under control. Food allergies may also play a role in adult acne, and people may want to avoid foods that appear to make their symptoms worse.
- Zinc (30 mg, 2 times per day for a month, then 30 mg per day). Several studies indicate that the mineral zinc may reduce the effects of acne. However, high doses of zinc can cause anemia, vomiting, and immune system suppression. It also interacts with tetracycline, which is often prescribed for acne. Taking more than 100 mg of supplemental zinc daily, or taking supplemental zinc for 10 years or more, doubles the risk of developing prostate cancer. There is also concern that taking large amounts of a multivitamin plus a separate zinc supplement increases the chances of dying from prostate cancer. For these reasons, talk to your doctor before taking zinc. Zinc can interfere with some medicines and other minerals, including certain antibiotics, and potentially Cisplatin. Speak with your doctor.
- Niacinamide (as a 4% topical gel). One study found that applying a 4% niacinamide gel to the skin twice daily for 2 months significantly improved acne symptoms. However, the study lacked a placebo, so it is hard to say how effective topical niacinamide might be on its own.
- L-carnitine. Researchers in Greece showed that, among a large group of people, mild side effects from isotretinoin (Accutane), such as dry skin, chapped lips, dry eyes, and nosebleeds caused by dry nose, improved when taking L-carnitine compared to those who took a placebo. L-carnitine may interfere with some medicines, including thyroid hormone, warfarin (Coumadin), and Acenocoumarol (Sintrom). L-carnitine may increase the risk of seizures in people who have previously had seizures.
- Vitamin A. Vitamin A has many of the same properties as the retinoid drugs, but often with fewer side effects. Few studies have been done on vitamin A and acne, however. Too much vitamin A can be toxic, so talk to your doctor to determine the right dose for you, and only take high doses of vitamin A under a doctor's supervision. It is especially important that you do not combine vitamin A supplementation and retinoid medicines for acne. DO NOT take extra vitamin A if you are pregnant or have liver disease.
Herbs may help strengthen and tone the body's systems. As with any therapy, you should work with your health care provider before starting treatment. You may use herbs as dried extracts (capsules, powders, or teas), glycerites (glycerine extracts), or tinctures (alcohol extracts). Unless otherwise indicated, make teas with 1 tsp. herb per cup of hot water. Steep covered 5 to 10 minutes for leaf or flowers, and 10 to 20 minutes for roots. Drink 2 to 4 cups per day. You may use tinctures alone or in combination as noted.
- Tea tree oil (Melaleuca alternafolia, 5% gel). Applied to the skin, tea tree oil may help reduce bacteria, reducing inflammation and improving symptoms. One study compared the effectiveness of tea tree oil gel with benzoyl peroxide lotion in 119 people with mild-to-moderate acne. People in both groups improved, and the people using tea tree oil reported fewer side effects (including stinging, itching, burning, and dryness) than those using benzoyl peroxide.
- Guggul (Commiphora mukul, dose equivalent to 25 mg guggulsterones or about 500 mg of guggul, 2 times per day). In one study, taking guggul orally had the same effect as taking tetracycline. You should not take guggul if you are pregnant or nursing. Guggul may have estrogen-like effects, and should not be taken by anyone with a history or family history of hormone-related cancers, including prostate, breast, or ovarian cancer. In addition, the herb may interact with anticoagulants (blood-thinning medicines), tamoxifen, and birth control pills containing estrogen, as well as herbs that have estrogen-like effects (such as black cohosh, licorice, soy, and others). People who take these herbs or drugs should not take guggul. Guggul can slow blood clotting, and may increase the risk of bleeding in those with bleeding disorders, or those who take blood-thinning medicines, such as warfarin (Coumadin) and aspirin.
- Ayurvedic medicine. Ayurvedic medicine may help improve symptoms. More studies are needed. In one study, a combination of ginger(Zingiber officinale), Holarrhena antidysenterica, and Embelia ribes reduced the number of inflammatory and noninflammatory lesions. In another study, combined oral and topical use of Aloe barbadensis, Azardirachta indica, turmeric (Curcuma longa), Hemidesmus indicus, Terminalia chebula, Terminalia arjuna, and ashwagandha (Withania somnifera) also reduced the number of lesions. Some of these herbs may have side effects, or may interact with certain medicines. Speak with your physician.
Few studies have examined the effectiveness of specific homeopathic remedies. Professional homeopaths, however, may recommend one or more of the following treatments for acne based on their knowledge and clinical experience. Before prescribing a remedy, homeopaths take into account a person's constitutional type. In homeopathic terms, a person's constitution is his or her physical, emotional, and intellectual makeup. An experienced homeopath assesses all of these factors when determining the most appropriate remedy for a particular individual.
- Belladonna, for people who experience flushes of heat to the face, or who have inflamed pustular acne that improves with cold applications
- Calendula, for skin conditions involving pustules or blisters
- Hepar sulphur, for painful, pus-filled acne
- Kali bromatum, for deep acne, especially on the forehead, in people who are chilled and nervous
- Silicea, for pustules or pit-forming acne
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