Linagliptin/metformin (By mouth)


Linagliptin (lin-a-GLIP-tin), Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide)

Treats type 2 diabetes. Used together with proper diet and exercise to control high blood sugar.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine


  • Take your medicine as directed.
  • It is best to take this medicine with food or milk.
  • Carefully follow your doctor's instructions about any special diet, exercise, or weight loss. Test your blood sugar regularly.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use insulin or diabetes medicine that you take by mouth, such as glimepiride, glipizide, glyburide, or Amaryl®.
  • Make sure your doctor knows if you are also using acetazolamide (Diamox®), cimetidine (Tagamet®), dichlorphenamide (Daranide®), digoxin (Lanoxin®), morphine, procainamide (Pronestyl®), quinidine (Quinidex®), quinine (Qualaquin®), ranitidine (Zantac®), rifampin (Rifadin®, Rimactane®), topiramate (Topamax®), trimethoprim (Bactrim®, Primsol®, Proloprim®, Septra®), vancomycin (Vancocin®), zonisamide (Zonegram®), or blood pressure medicine (such as amlodipine, atenolol, diltiazem, metoprolol, nifedipine, propranolol, timolol, verapamil, Caduet®, Lotrel®).
  • Some medicines affect your blood sugar level, so they might also affect how this medicine works. Tell your doctor if you are taking a vitamin B supplement, phenytoin (Dilantin®), isoniazid (Nydrazid®), a diuretic (water pill, such as amiloride, furosemide, hydrochlorothiazide, triamterene, Lasix®), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone, Medrol®), a phenothiazine medicine (such as prochlorperazine, promethazine, Phenergan®, Thorazine®), thyroid replacement (such as levothyroxine, liothyronine, Cytomel®, Synthroid®), estrogen, or birth control pills.
  • Limit how much alcohol you drink, because alcohol can increase your risk of serious side effects.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney problems, liver disease, vitamin B12 deficiency, heart failure, problems with your adrenal or pituitary gland, or a history of alcoholism.
  • Rarely, this medicine may cause a serious condition called lactic acidosis. Call your doctor right away if you feel sick and drowsy, have muscle pain, changes in breathing, dizziness or lightheadedness, upset stomach, and slow heartbeat. Lactic acidosis is more likely to happen if you have kidney or liver problems, a severe infection (sepsis), severe heart failure, are severely dehydrated, or drink large amounts of alcohol. You could also have more side effects from this medicine if you have to stop eating or drinking for a medical procedure or test.
  • Pancreatitis may occur while you are using this medicine. Stop taking this medicine and call your doctor right away if you have sudden and severe stomach pain, nausea, vomiting, fever, or lightheadedness. Tell your doctor if you drink alcohol or have gallstones, high cholesterol, or high triglycerides, or if you have had pancreas problems before. These conditions may increase your risk for pancreatitis.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an X-ray or a CT scan. You may need to stop using this medicine several days before you have surgery or medical tests.
  • You could develop low blood sugar while you are taking this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Tell your doctor if this happens. Low blood sugar may be caused by exercising more than normal or waiting too long to eat.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Tell your doctor if you have a fever, any kind of infection, or an injury while you are using this medicine, because these can change your blood sugar levels.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Changes in breathing, trouble breathing, nausea, vomiting, slow or uneven heartbeat
  • Decrease in how much or how often you urinate
  • Extreme weakness, tiredness, or confusion
  • Feeling cold, dizzy, drowsy, or lightheaded
  • Low blood sugar levels: Shaking, trembling, sweating, fast or pounding heartbeat, faintness or lightheadedness, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Stuffy or runny nose

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 4/4/2014

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.